Although alcohol and tobacco use account for majority of patients with squamous cell carcinoma of the head and neck, HPV is now recognized as a major factor in the development of the majority of head neck squamous cell carcinoma’s of the oropharynx in North America and Europe. It is expected that the incidence will surpass the incidence of cervical cancer by 2020. Alcohol and tobacco usage have been associated with increased incidence of HPV unrelated head and neck squamous cell carcinoma. HPV tumor status has been associated with favorable prognosis in terms of treatment and survival.though it is associated with a favorable initial response to therapy approximately 30% of patients well unfortunately experience we currents. It is too early to determine the definite value of HPV vaccination initiatives in terms of oro-pharyngeal cancer.